Description
Technical Monograph: F-DRI-10 | Selective Apoptotic Reagent
Product Code: HRL-FOX-10 | Total Peptide Mass: 10 mg
This high-purity D-Retro-Inverso (DRI) isoform peptide is engineered for advanced research into cellular senescence and programmed cell death. By specifically disrupting the interaction between the FOXO4 transcription factor and the p53 tumor suppressor protein, this 10 mg variant allows for the study of targeted apoptosis in non-proliferative cellular models.
Molecular Specification & Composition
| Attribute | Technical Detail |
| Peptide Type | D-Retro-Inverso (DRI) Isoform |
| Purity (HPLC) | >99.0% |
| Molecular Weight | 5358.2 g/mol |
| Total Mass | 10 mg Lyophilized Powder |
Analytical Characteristics
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Enhanced Proteolytic Resistance: The DRI configuration is specifically engineered to resist enzymatic degradation by endogenous proteases, ensuring high stability in various research media.
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Targeted Signaling Disruption: Optimized for the evaluation of the FOXO4/p53 axis, facilitating the release of p53 into the nucleus for mitochondrial-mediated apoptosis studies.
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Selective Model Utility: Formulated to observe the clearance of damaged cellular populations without impacting healthy, proliferating cell lines.
Laboratory Application Fields
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Cellular Senescence Modeling: Investigating the “Senolytic” pathway and the selective removal of senescent cells in vitro.
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Apoptotic Pathway Mapping: Analysis of p53-mediated cell death mechanisms and mitochondrial membrane permeability.
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Longevity Signaling Research: Studying the impact of FOXO4 inhibition on tissue-level homeostasis and protein-synthesis restoration.
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Epigenetic Stability Studies: Evaluation of the peptide’s influence on transcription factor localization and gene expression.
Storage & Handling Protocols
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Thermal Management: Store lyophilized vials at -20°C for maximum molecular integrity.
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Reconstitution: Maintain at 2-8°C post-reconstitution. Due to the complex DRI structure, ensure complete dissolution in 0.9% NaCl or sterile laboratory water before application.
IMPORTANT NOTICE & DISCLAIMER
FOR LABORATORY RESEARCH USE ONLY. This product is a synthesized chemical reagent intended solely for in vitro laboratory research and analytical testing. It is NOT a drug, food, or cosmetic, and it is NOT intended for human consumption, inhalation, or any form of internal or external application to humans or animals.
Any use of this product outside of a controlled laboratory setting is strictly prohibited. The purchaser assumes all responsibility for the handling, storage, and regulatory compliance of this compound. Hudson Research Lab does not provide medical advice or instructions for human application. Keep out of reach of children.
